Deng Shi-Zhou, Bai Wen-Jun, Wang Xiao-Feng
Department of Urology, People's Hospitial, Peking University, Beijing 100044, China.
Zhonghua Nan Ke Xue. 2007 Jul;13(7):643-6.
Animal models in sexual dysfunction were reviewed to further improve the modeling methods and to promote the effectiveness of drug evaluation translation from animal models to humans. A MEDLINE search was performed to retrieve articles relating to animal models in sexual dysfunction. Researches on a variety of animal models in sexual dysfunction, with their own merits, has to a certain extent contributed to the understanding of sexual function. However, no models could give a fully accurate assessment of sexual function. The existing sexual function studies on animal models of interpretive function, the development mechanisms, the effects of drugs on sexual function and the clinical translation still have some deficiencies, but with their basic principles and ideas for the improvement of the models and the preservation of the valuable data of drugs and clinical trials.
对性功能障碍动物模型进行了综述,以进一步改进建模方法,并提高从动物模型到人类的药物评价转化的有效性。进行了MEDLINE检索,以检索与性功能障碍动物模型相关的文章。对各种性功能障碍动物模型的研究各有其优点,在一定程度上有助于对性功能的理解。然而,没有一种模型能够对性功能进行完全准确的评估。现有的关于动物模型性功能的解释功能、发育机制、药物对性功能的影响以及临床转化的研究仍存在一些不足,但保留了其改进模型的基本原则和思路以及药物和临床试验的宝贵数据。