Van Den Eede Filip, Venken Tine, Van Den Bogaert Ann, Del-Favero Jurgen, Norrback Karl-Fredrik, Nilsson Lars Göran, Adolfsson Rolf, Van Broeckhoven Christine, Claes Stephan J
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerp, Belgium.
Psychiatr Genet. 2007 Oct;17(5):304-7. doi: 10.1097/YPG.0b013e328133f342.
Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder.
促肾上腺皮质激素释放因子结合蛋白调节游离促肾上腺皮质激素释放因子的可用性，是情感障碍的一个功能性候选基因。本研究的目的是在一个孤立的瑞典人群中检测促肾上腺皮质激素释放因子结合蛋白（CRF-BP）基因多态性与双相情感障碍之间的关联。该研究纳入了182例I型双相情感障碍患者和333名来自瑞典北部的对照。对CRF-BP基因中的5个单核苷酸多态性和一个缺失多态性进行了基因分型。考虑了该基因的单倍型模块结构，并采用期望最大化算法来估计单倍型频率。结果，CRF-BP基因中不同的多态性与双相情感障碍之间没有显著关联。总之，这项在孤立瑞典人群中的研究不支持CRF-BP基因在双相情感障碍易感性中起作用。
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