Science. 1945 Oct 5;102(2649):352-3. doi: 10.1126/science.102.2649.352.
The failure of even special methods to induce infection indicates that not all strains of young white laboratory mice (Mus musculus) are uniformly susceptible to fatal infection with Leptospira icterohemorrhagiae. Some strains of this species develop early pathological changes characteristic of the infection and harbor the organism in their kidneys, but do not succumb. Therefore not all strains of white mice are suitable for use in the diagnostic mouse protection test for leptospirosis described by Larson.
即使采用特殊方法也未能诱发感染,这表明并非所有幼年白色实验鼠(Mus musculus)品系都对黄疸出血性钩端螺旋体的致死性感染具有均匀的易感性。该物种的某些品系会发生感染的早期病理变化,并在其肾脏中携带该病原体,但不会屈服。因此,并非所有白色小鼠品系都适合用于拉尔森(Larson)所描述的钩端螺旋体病诊断性小鼠保护试验。