Effect of cholesterol feeding on the compositions of plasma lipoproteins and plasma lipolytic activities in SHRSP.

By cholesterol feeding, atherogenic VLDL, beta-VLDL (IDL) and LDL increased more remarkably in SHRSP than in normotensive WKY, suggesting that hypertension may promote the productions of atherogenic lipoproteins. On the other hand, HDL significantly decreased in SHRSP, which was associated with the decrease in apoA-I and E in the HDL fraction. This indicates the decreases of two HDL subfractions, apoE HDL and apoA-I HDL, in SHRSP. These decreases of HDL subfractions in SHRSP may be closely related to the higher h-TGL activity in SHRSP than in WKY, and could be a trigger of the excess production of atherogenic lipoproteins.