大鼠脊髓锥体束和非锥体束的电生理评估。

The electrophysiological assessment of the pyramidal and non-pyramidal tracts of the spinal cord of rats.

作者信息

Fehlings M G, Hurlbert R J, Tator C H

机构信息

Canadian Paraplegic Association Spinal Cord Research Laboratory, Toronto Western Hospital, University of Toronto, Ontario, Canada.

出版信息

Electroencephalogr Clin Neurophysiol Suppl. 1991;43:287-96.

PMID:1773766

Abstract

The present paper summarizes our experience with the use of motor evoked potentials (MEP) and cerebellar evoked potentials (CEP) to assess the physiological integrity of the motor tracts of the spinal cord in a rat model. The MEP elicited by intracortical microstimulation of motor cortex reflected activity only in the pyramidal tracts; in contrast the MEP obtained by extradural cortical stimulation with a macroelectrode also reflected activity in a number of non-pyramidal pathways including the lateral vestibulospinal and rubrospinal tracts. The CEP was principally conducted in ventral spinal cord tracts and may reflect direct activation of brainstem nuclei. Data are presented which correlate the relationship between the MEP and axonal integrity after cord injury.

摘要

本文总结了我们在大鼠模型中使用运动诱发电位（MEP）和小脑诱发电位（CEP）评估脊髓运动传导束生理完整性的经验。通过皮层内微刺激运动皮层引出的MEP仅反映锥体束的活动；相比之下，用宏观电极进行硬膜外皮层刺激获得的MEP还反映了包括外侧前庭脊髓束和红核脊髓束在内的一些非锥体束通路的活动。CEP主要在脊髓腹侧束中传导，可能反映脑干核团的直接激活。文中给出的数据表明了脊髓损伤后MEP与轴突完整性之间的关系。