Vitek V, Lang D J
J Clin Endocrinol Metab. 1976 Apr;42(4):781-4. doi: 10.1210/jcem-42-4-781.
The urinary excretion of cyclic AMP was investigated in 97 healthy children, 3 months to 16 years old. When the excretion was expressed as mumol/24 h an increase with age (r = 0.693, P less than 0.001) and an increase with body weight (r = 0.700, P less than 0.001) were found to be quite similar. In relation to surface area, the average excretion for children up to 91/2 years old was 4.45 +/- 1.71 mumol/m2 in constrast with 2.22 +/- 0.66 mumol/m2 in older children (P less than 0.001). The decline appears to be associated with approaching puberty. When cAMP excretion was related to urinary creatinine, an inverse correlation with age was found (r = -0.772, P less than 0.001). In the youngest category, 3 months to 4 years old, the ratio was 9.26 +/- 1.49 mumol/g creatinine vs 4.67 +/- 1.05 mumol/g creatinine in the age group 12 to 16 years old (P less than 0.001), which compares closely with the normal adult average of 4.34 +/- 1.25 mumol/g creatinine found in our previous study. Throughout there was no evidence of sex differentiation.
对97名年龄在3个月至16岁的健康儿童的环磷酸腺苷（cAMP）尿排泄情况进行了研究。当排泄量以微摩尔/24小时表示时，发现其随年龄增加（r = 0.693，P < 0.001）以及随体重增加（r = 0.700，P < 0.001）的情况非常相似。就体表面积而言，9岁半以下儿童的平均排泄量为4.45±1.71微摩尔/平方米，而年龄较大儿童为2.22±0.66微摩尔/平方米（P < 0.001）。这种下降似乎与接近青春期有关。当cAMP排泄量与尿肌酐相关时，发现其与年龄呈负相关（r = -0.772，P < 0.001）。在最年幼的年龄组，即3个月至4岁，该比值为9.26±1.49微摩尔/克肌酐，而在12至16岁年龄组为4.67±1.05微摩尔/克肌酐（P < 0.001），这与我们之前研究中发现的正常成人平均值4.34±1.25微摩尔/克肌酐非常接近。总体而言，没有性别差异的证据。
