Preliminary Studies on the Absorption and Excretion of Streptomycin in Dogs.

Streptomycin varying in potency from 100 to 500 units/mg. has been administered to 14 dogs intravenously, intramuscularly, and orally in amounts of 100,000 to 420,000 units. High blood levels of streptomycin were observed after parenteral administration and 23 to 65 per cent was excreted in the urine of normal dogs. After 4 or 5 hours only small amounts were detected in the blood. The maintenance of blood levels was no better with intramuscular than with intravenous administration. Following the oral administration of as much as 420,000 units of streptomycin, it could not be detected in the plasma, but up to 3.9 per cent was recovered from the urine.