Science. 1975 Mar 28;187(4182):1203-6. doi: 10.1126/science.187.4182.1203.
Chromatin prepared by a method involving limited nuclease digestion contains the same repeating structure as chromatin in the nucleus, whereas chromatin prepared by conventional methods involving shear does not.
通过一种涉及有限核酸酶消化的方法制备的染色质与核内染色质具有相同的重复结构,而通过传统的涉及剪切的方法制备的染色质则没有。