锥虫和利什曼原虫中基因表达的转录后调控
Post-transcriptional regulation of gene expression in trypanosomes and leishmanias.
作者信息
Clayton Christine, Shapira Michal
机构信息
Zentrum für Molekualre Biologie der Universität Heidelberg, Im Neuenheimer Feld 282, D69120 Heidelberg, Germany.
出版信息
Mol Biochem Parasitol. 2007 Dec;156(2):93-101. doi: 10.1016/j.molbiopara.2007.07.007. Epub 2007 Jul 19.
Gene expression in Kinetoplastids is very unusual in that the open reading frames are arranged in long polycistronic arrays, monocistronic mRNAs being created by post-transcriptional processing. Thus the regulation of gene expression is post-transcriptional. We here discuss recent results concerning the enzymes required for mRNA degradation, and components of the translation initiation machinery, and how both are regulated.
动质体中的基因表达非常独特，其开放阅读框排列成长的多顺反子阵列，单顺反子mRNA通过转录后加工产生。因此，基因表达的调控是转录后水平的。我们在此讨论关于mRNA降解所需的酶、翻译起始机制的组成部分以及两者如何被调控的最新研究结果。
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