精神分裂症患者后代的尾状核体积

Caudate volume in offspring of patients with schizophrenia.

作者信息

Rajarethinam Rajaprabhakaran, Upadhyaya Ameet, Tsou Pon, Upadhyaya Margie, Keshavan Matcheri S

机构信息

Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Street UHC-9B, Detroit, Michigan 48201, USA.

出版信息

Br J Psychiatry. 2007 Sep;191:258-9. doi: 10.1192/bjp.bp.106.029017.

DOI:10.1192/bjp.bp.106.029017

PMID:17766768

Abstract

Caudate nuclei are smaller in drug-naive people with schizophrenia but larger in antipsychotic-treated patients. In this magnetic resonance imaging study we found volume reduction of right and left caudate by 8.9 and 8.1% respectively in 50 offspring without psychosis of patients with schizophrenia compared with 53 age- and gender-matched controls, providing new evidence that caudate volume reduction may be a trait-related abnormality in schizophrenia.

摘要

在未服用药物的精神分裂症患者中，尾状核较小，但在接受抗精神病药物治疗的患者中则较大。在这项磁共振成像研究中，我们发现，与53名年龄和性别匹配的对照组相比，50名精神分裂症患者未患精神病的后代中，左右尾状核体积分别减少了8.9%和8.1%，这为尾状核体积减少可能是精神分裂症中与特质相关的异常提供了新证据。