HLA - A020115和HLA - Cw030203在第4外显子中显示出新的同义突变。

HLA-A020115 and HLA-Cw030203 show new synonymous mutations in exon 4.

作者信息

Balas A, Bustamante L, García-Sánchez F, Vicario J L

机构信息

Departamento de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, 20832 Madrid, Spain.

出版信息

Tissue Antigens. 2007 Oct;70(4):340-1. doi: 10.1111/j.1399-0039.2007.00906.x.

DOI:10.1111/j.1399-0039.2007.00906.x

PMID:17767559

Abstract

Two novel human leukocyte antigen (HLA) class I alleles, A020115 and Cw030203, were completely characterized by sequencing-based typing. Both present synonymous new HLA polymorphisms at exon 4. A020115 shows a single nucleotide change regarding A02010101 at codon 245 GCG > GCC). In contrast, Cw030203 differs from Cw030202 in a point mutation at codon 271 (ACC > ACT).

摘要

通过基于测序的分型对两个新的人类白细胞抗原（HLA）I类等位基因A020115和Cw030203进行了全面鉴定。两者在第4外显子均呈现同义的新HLA多态性。A020115在密码子245处（GCG > GCC）相对于A02010101有一个单核苷酸变化。相比之下，Cw030203在密码子271处（ACC > ACT）的一个点突变上与Cw030202不同。