Darke Shane, Duflou Johan, Kaye Sharlene
National Drug and Alcohol Research Centre, University of New South Wales, NSW, Australia.
Addiction. 2007 Nov;102(11):1793-7. doi: 10.1111/j.1360-0443.2007.01980.x. Epub 2007 Sep 3.
To compare the blood toxicology of heroin overdose cases and morphine positive homicide victims.
Analysis of coronial cases.
Sydney, Australia. Cases A total of 705 cases of death due to opioid toxicity and 28 morphine positive homicide cases (1 January 1998-31 December 2002).
There was no significant difference between the median morphine concentrations of the overdose and homicide groups (0.50 versus 0.45 mg/l). The overdose group was more likely to have blood alcohol (OR 3.21) present, but less likely to have methadone (OR 0.26) and cannabis (OR 0.04). There was a significant negative correlation between blood morphine and alcohol concentrations among the overdose group (rho = -0.32), but not among the homicide group (rho = -0.03). Independent predictors of a higher blood morphine concentration were a lower alcohol concentration and a higher methadone concentration.
Morphine concentrations per se are not diagnostic of overdose. The study confirms the salience of concomitant alcohol consumption in such events.
比较海洛因过量用药病例与吗啡呈阳性的凶杀案受害者的血液毒理学情况。
对死因裁判法庭案件进行分析。
澳大利亚悉尼。病例 共有 705 例阿片类药物中毒致死病例以及 28 例吗啡呈阳性的凶杀案病例（1998 年 1 月 1 日至 2002 年 12 月 31 日）。
过量用药组与凶杀案组的吗啡浓度中位数无显著差异（分别为 0.50 毫克/升和 0.45 毫克/升）。过量用药组血液中更可能含有酒精（比值比 3.21），但含有美沙酮（比值比 0.26）和大麻（比值比 0.04）的可能性较小。在过量用药组中，血液吗啡浓度与酒精浓度之间存在显著负相关（相关系数 ρ = -0.32），而在凶杀案组中则无此相关性（相关系数 ρ = -0.03）。血液吗啡浓度较高的独立预测因素是酒精浓度较低和美沙酮浓度较高。
吗啡浓度本身并不能诊断过量用药情况。该研究证实了此类事件中同时饮酒的显著性。
Zotero 插件