Science. 1965 Jan 15;147(3655):306-7. doi: 10.1126/science.147.3655.306.
Male rats castrated within 4 days after birth are behaviorally feminized. On the other hand, intact or castrated males given estrogen neonatally show little estrous behavior in adulthood. Thus, feminization is induced by lack of neonatal androgen rather than by the presence of estrogen. Estrogen administered to newborn rats suppresses feminization.
新生 4 天内被去势的雄性大鼠的行为表现出雌性化。另一方面,在新生期给予雌激素的未去势或去势雄性大鼠在成年后很少出现发情行为。因此,雌性化是由新生儿雄激素缺乏引起的,而不是雌激素的存在引起的。给予新生大鼠雌激素可抑制雌性化。