造血干细胞移植受者无症状人偏肺病毒感染的长期研究。
Long-term study on symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients.
作者信息
Debiaggi Maurizia, Canducci Filippo, Terulla Cristina, Sampaolo Michela, Marinozzi Maria Chiara, Alessandrino Paolo Emilio, Colombo Anna Amelia, Caldera Daniela, Bragotti Letizia Zenone, Migliavacca Roberta, Bianchi Emanuela, Romero Egidio, Clementi Massimo
机构信息
Dipartimento Scienze Morfologiche Eidologiche e Cliniche, Sezione Microbiologia, Università di Pavia, Italy.
出版信息
New Microbiol. 2007 Jul;30(3):255-8.
From October 2004 through October 2006 a study was performed to evaluate the prevalence of human Metapneumovirus (hMPV) infection in adult hematopoietic stem cell transplant (HSCT) recipients. Sequential nasopharyngeal aspirates (NPA) were collected independently from respiratory symptoms and evaluated for hMPV-RNA by polymerase chain reaction (PCR) and sequence analysis. Results indicate epidemiological and molecular differences between the 2004-2005 and 2005-2006 periods and that hMPV seems not to symptomatically affect HSCT patients or cause late respiratory sequelae. In addition, data collected suggest a hospital origin of hMPV infection in most HSCT patients during the 2004-2005 period.
2004年10月至2006年10月期间，开展了一项研究以评估成人造血干细胞移植（HSCT）受者中人偏肺病毒（hMPV）感染的患病率。从出现呼吸道症状的患者中独立采集序贯鼻咽抽吸物（NPA），并通过聚合酶链反应（PCR）和序列分析评估hMPV-RNA。结果表明，2004 - 2005年和2005 - 2006年期间存在流行病学和分子差异，并且hMPV似乎不会对HSCT患者产生症状性影响或导致晚期呼吸道后遗症。此外，收集的数据表明，在2004 - 2005年期间，大多数HSCT患者的hMPV感染源自医院。
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