[Immunologic reactivity in patients with disseminated pulmonary tuberculosis with polysensitization].

Study of immunologic reactivity in patients with disseminated pulmonary tuberculosis has demonstrated that 80% of patients have sensitization to Mycobacterium tuberculosis antigens, in addition to that to bacterial flora (Streptococcus, Staphylococcus, Pneumococcus). The degree of immunity system damage depends on the character of the course and dissemination of the pathologic process. Three degrees of immunity system damage were distinguished: sharply manifested degree with suppression of all types of cellular immune response and activation of humoral immunity, which is seen in patients with bilateral caseous pneumonia and military pulmonary tuberculosis; manifested degree with suppression of cellular immunity, natural organism's resistance and moderate decrease of humoral immunity typical of subacute disseminated pulmonary tuberculosis; moderate degree with mild changes in cellular and humoral immune response and natural organism's resistance and high sensitization in the lymphocyte blast transformation reaction with specific antigen, which occurs in chronic disseminated pulmonary tuberculosis.