Rycroft A N, Williams D, McCandlish I A, Taylor D J
Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden.
Vet Rec. 1991 Nov 16;129(20):441-3. doi: 10.1136/vr.129.20.441.
The role of the heat-labile haemolysin of Actinobacillus pleuropneumoniae in acute porcine pleuropneumonia was examined. A virulent strain was compared with an isogenic haemolysin-deficient mutant in experimental infections. The pigs which received the virulent strain showed clinical signs of acute respiratory disease whereas the animals infected with the mutant strain appeared to be less severely affected. At post mortem examination, both groups showed similar acute pulmonary lesions and pleurisy typical of A pleuropneumoniae infection. The bacterial antigen representing the haemolysin was detected in lung lesions infected with the parent strain but not in those infected with the mutant. These results demonstrate that the haemolysin of serotype 2 A pleuropneumoniae is not an essential factor for the production of the lesions of pleuropneumonia in pigs.
研究了胸膜肺炎放线杆菌的不耐热溶血素在猪急性胸膜肺炎中的作用。在实验性感染中，将一株强毒株与一株同基因溶血素缺陷型突变株进行了比较。接种强毒株的猪表现出急性呼吸道疾病的临床症状，而感染突变株的动物似乎受到的影响较小。尸检时，两组均表现出类似的急性肺部病变和典型的胸膜肺炎放线杆菌感染引起的胸膜炎。在感染亲本菌株的肺部病变中检测到代表溶血素的细菌抗原，而在感染突变株的病变中未检测到。这些结果表明，2型胸膜肺炎放线杆菌的溶血素不是猪胸膜肺炎病变产生的必需因素。
