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开腹与腹腔镜胃旁路手术中肺栓塞的发生率

The incidence of pulmonary embolism in open versus laparoscopic gastric bypass.

作者信息

Gargiulo Nicholas J, Veith Frank J, Lipsitz Evan C, Suggs William D, Ohki Takao, Goodman Elliot, Vemulapalli Pratt, Gibbs Karen, Teixeira Julio

机构信息

Division of Vascular Surgery, Montefiore Medical Center, Bronx, NY 10467, USA.

出版信息

Ann Vasc Surg. 2007 Sep;21(5):556-9. doi: 10.1016/j.avsg.2007.07.003.

Abstract

Obesity independently increases the risk of pulmonary embolism (PE). We compare a superobese population (body mass index [BMI] > 55 kg/m(2)) undergoing open gastric bypasses (OGBs) with a similarly matched group of laparoscopic gastric bypasses (LGB) to see if the incidence of PE differs. We included all patients undergoing OGB (n = 193, average BMI = 51 kg/m(2)) at our institution by a single surgeon between July 1999 and April 2001. Thirty-one patients were superobese (BMI > 55 kg/m(2)). LGB was started at our institution in April 2001. Since that time 213 patients (average BMI = 52 kg/m(2)) have undergone the procedure. One hundred and nine patients were superobese. Pre- and postoperative prophylaxis included sequential compression stockings and subcutaneous heparin. Postoperatively, patients who developed signs of hypoxia, tachypnea, or tachycardia underwent a chest X-ray and spiral computed tomography. In addition, all patients who expired in the 30-day postoperative period underwent postmortem examination. Data were analyzed using the chi-squared test. In the OGB group, four patients (2.1%) developed PE. All occurred in superobese patients with a BMI > 55 kg/m(2). Three were fatal PEs and one was nonfatal. None of these patients had a prior history of deep vein thrombosis, PE, venous stasis disease, or pulmonary hypertension. In the LGB group, one patient (0.9%) had a nonfatal PE. This patient had a history of deep vein thrombosis. The incidence of PE was statistically higher in the superobese OGB group (P < 0.01). Despite the theoretical hindrance to venous return and vena caval compression observed with pneumoperitoneum, fewer PEs occurred in the laparoscopic group. Our data, however, suggest that patients with a BMI > 55 kg/m(2) might be at an increased risk for PE independent of operative approach.

摘要

肥胖会独立增加肺栓塞(PE)的风险。我们将接受开放式胃旁路手术(OGB)的超级肥胖人群(体重指数[BMI]>55kg/m²)与一组匹配的腹腔镜胃旁路手术(LGB)患者进行比较,以观察PE的发生率是否存在差异。我们纳入了1999年7月至2001年4月期间在我们机构由一位外科医生进行OGB手术的所有患者(n = 193,平均BMI = 51kg/m²)。其中31例患者为超级肥胖(BMI>55kg/m²)。LGB手术于2001年4月在我们机构开展。自那时起,213例患者(平均BMI = 52kg/m²)接受了该手术。其中109例患者为超级肥胖。术前和术后预防措施包括使用序贯加压弹力袜和皮下注射肝素。术后,出现缺氧、呼吸急促或心动过速症状的患者接受胸部X光和螺旋计算机断层扫描。此外,所有在术后30天内死亡的患者均接受尸检。数据采用卡方检验进行分析。在OGB组中,4例患者(2.1%)发生了PE。所有病例均发生在BMI>55kg/m²的超级肥胖患者中。3例为致命性PE,1例为非致命性PE。这些患者均无深静脉血栓形成、PE、静脉淤滞疾病或肺动脉高压的既往史。在LGB组中,1例患者(0.9%)发生了非致命性PE。该患者有深静脉血栓形成病史。超级肥胖的OGB组中PE的发生率在统计学上更高(P<0.01)。尽管气腹观察到理论上对静脉回流和腔静脉压迫有阻碍,但腹腔镜组发生的PE较少。然而,我们的数据表明,BMI>55kg/m²的患者可能独立于手术方式而发生PE的风险增加。

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