Lorefält B, Toss G, Granérus A-K
Department of Medicine and Care, Linköping University, Sweden.
Acta Neurol Scand. 2007 Oct;116(4):248-54. doi: 10.1111/j.1600-0404.2007.00875.x.
The objective of the present study was to find risk factors for low bone mineral density (BMD) in patients with Parkinson's disease (PD).
Twenty-six PD patients and 26 age-and sex-matched healthy controls were assessed twice within a 1-year period. PD symptoms, body weight, body fat mass, BMD, physical activity, smoking and serum concentrations of several laboratory analyses were investigated.
BMD in different locations was lower in PD patients compared with their controls and decreased during the investigated year. BMD was lower in PD patients with low body weight. BMD Z-score of trochanter in the PD group was directly correlated to the degree of physical activity and indirectly to the length of recumbent rest. Total body BMD Z-score in the PD group was directly correlated to the degree of rigidity. Serum 25-hydroxy-vitamin D was slightly lower in PD patients.
Low body weight and low physical activity were risk factors for low BMD in PD, while rigidity seemed to be protective.
本研究的目的是寻找帕金森病（PD）患者低骨矿物质密度（BMD）的危险因素。
26例PD患者和26例年龄及性别匹配的健康对照者在1年内接受了两次评估。对PD症状、体重、体脂量、BMD、身体活动、吸烟情况以及多项实验室分析的血清浓度进行了调查。
与对照组相比，PD患者不同部位的BMD较低，且在研究年度内有所下降。体重低的PD患者BMD较低。PD组大转子的BMD Z评分与身体活动程度直接相关，与卧位休息时间间接相关。PD组全身BMD Z评分与僵硬程度直接相关。PD患者血清25-羟维生素D略低。
体重低和身体活动少是PD患者BMD低的危险因素，而僵硬似乎具有保护作用。
