Singh Seema, Sadanandam Anguraj, Singh Rakesh K
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5845, USA.
Cancer Metastasis Rev. 2007 Dec;26(3-4):453-67. doi: 10.1007/s10555-007-9068-9.
Chemokines are a large group of low molecular weight cytokines that are known to selectively attract and activate different cell types. Although the primary function of chemokines is well recognized as leukocyte attractants, recent evidences indicate that they also play a role in number of tumor-related processes, such as growth, angiogenesis and metastasis. Chemokines activate cells through cell surface seven trans-membranes, G-protein-coupled receptors (GPCR). The role played by chemokines and their receptors in tumor pathophysiology is complex as some chemokines favor tumor growth and metastasis, while others may enhance anti-tumor immunity. These diverse functions of chemokines establish them as key mediators between the tumor cells and their microenvironment and play critical role in tumor progression and metastasis. In this review, we present some of the recent advances in chemokine research with special emphasis on its role in tumor angiogenesis and metastasis.
趋化因子是一大类低分子量细胞因子，已知其能选择性地吸引和激活不同的细胞类型。尽管趋化因子的主要功能被公认为白细胞吸引剂，但最近的证据表明，它们也在许多与肿瘤相关的过程中发挥作用，如生长、血管生成和转移。趋化因子通过细胞表面的七次跨膜G蛋白偶联受体（GPCR）激活细胞。趋化因子及其受体在肿瘤病理生理学中所起的作用很复杂，因为一些趋化因子促进肿瘤生长和转移，而另一些可能增强抗肿瘤免疫力。趋化因子的这些多样功能使其成为肿瘤细胞与其微环境之间的关键介质，并在肿瘤进展和转移中起关键作用。在本综述中，我们介绍了趋化因子研究的一些最新进展，特别强调其在肿瘤血管生成和转移中的作用。
