西氯他宁对清醒去窦主动脉神经犬血管活性系统的影响。

Effects of cicletanine on vasoactive systems in conscious sinoaortic-denervated dogs.

作者信息

Damase-Michel C, Girolami J P, Bascands J L, Tran M A, Moatti J P, Pecher C, Berthet P, Tarrade T, Montastruc J L

机构信息

Laboratoire de pharmacologie médicale et clinique, INSERM U 317, Faculté de médecine, Toulouse, France.

出版信息

Fundam Clin Pharmacol. 1991;5(8):719-32. doi: 10.1111/j.1472-8206.1991.tb00760.x.

DOI:10.1111/j.1472-8206.1991.tb00760.x

PMID:1783361

Abstract

The present study investigates the antihypertensive action of cicletanine, a new antihypertensive compound with diuretic properties (or placebo), on vasopressor (catecholamines, renin-aldosterone) as well as vasodepressor (prostaglandins, kallikrein-kinin) systems in conscious chronic sinoaortic denervated (SAD) dogs. Cicletanine (10 mg/kg twice a day, per os, for one month) lowered blood pressure and heart rate. The antihypertensive action does not involve an effect on sympathetic tone (since plasma catecholamine levels were unmodified) or on plasma aldosterone levels. By contrast, urinary 6 keto PGF1 or PGE2 levels and kallikrein activity were enhanced. This result indicates that the antihypertensive effect of cicletanine is associated with a stimulation of potential vasodepressor systems (such as prostaglandins or kinins).

摘要

本研究探讨了环戊噻嗪（一种具有利尿特性的新型抗高血压化合物）（或安慰剂）对清醒慢性去窦主动脉神经支配（SAD）犬的血管升压系统（儿茶酚胺、肾素 - 醛固酮）以及血管降压系统（前列腺素、激肽释放酶 - 激肽）的抗高血压作用。环戊噻嗪（每天口服两次，每次10mg/kg，持续一个月）可降低血压和心率。其抗高血压作用并不涉及对交感神经张力（因为血浆儿茶酚胺水平未改变）或血浆醛固酮水平的影响。相反，尿中6 - 酮 - PGF1或PGE2水平以及激肽释放酶活性增强。这一结果表明，环戊噻嗪的抗高血压作用与对潜在血管降压系统（如前列腺素或激肽）的刺激有关。