Lam K M, Linna T J
Cancer Res. 1976 May;36(5):1710-3.
XC cells originally derived from the tumor of a rat previously inoculated with the Prague strain of Rous sarcoma virus were used to induce tumors in chickens surgically thymectomized or bursectomized in the newly hatched period. Thymectomized chickens had a significantly higher incidence of tumors, larger tumors, and a higher tumor mortality, compared with control chickens, when both groups were given 5 X 10(6) XC cells into the wing webs. Bursectomy could significantly influence the tumor size only. It appeared that the capacity of XC cells to induce tumors and the growth of such tumors were subject to immunological influence, with the thymus playing a major and the bursa of Fabricus a minor role under the conditions used.
XC细胞最初源自一只先前接种了劳斯肉瘤病毒布拉格株的大鼠的肿瘤，用于在新孵出时经手术切除胸腺或法氏囊的鸡中诱发肿瘤。当两组鸡的翼蹼都接种5×10⁶个XC细胞时，与对照鸡相比，切除胸腺的鸡的肿瘤发生率显著更高、肿瘤更大且肿瘤死亡率更高。切除法氏囊仅能显著影响肿瘤大小。在所用条件下，XC细胞诱发肿瘤的能力及其所诱发肿瘤的生长似乎受到免疫影响，其中胸腺起主要作用，法氏囊起次要作用。
