Hajòs M, Engberg G
Department of Physiology, A. Szent-Györgyi Medical University, Szeged, Hungary.
Pharmacol Biochem Behav. 1991 Jul;39(3):809-11. doi: 10.1016/0091-3057(91)90170-7.
The escape reaction, as an indicator of behavioral thermoregulation, was studied in rats pretreated with the selective noradrenergic neurotoxin DSP-4. The animals were kept for 30 min in a heated floor (42, 44, 46, 48 and 50 degrees C) cage containing a wooden platform placed at a height of 12 cm, which enabled the rats to escape from the warm floor. The latency of escape and the time spent on the platform were recorded. The performance of DSP-4-treated rats was significantly inferior to that of the control rats at all tested temperatures. These findings indicate a general function of the central noradrenergic neurons in defense alarm reactions, including a significant role in heat defense behavior.
作为行为体温调节指标的逃避反应，在经选择性去甲肾上腺素能神经毒素DSP-4预处理的大鼠中进行了研究。将动物置于一个加热地板（42、44、46、48和50摄氏度）的笼子里30分钟，笼子里有一个放置在12厘米高处的木制平台，这使得大鼠能够逃离温暖的地板。记录逃避潜伏期和在平台上花费的时间。在所有测试温度下，经DSP-4处理的大鼠的表现明显低于对照大鼠。这些发现表明中枢去甲肾上腺素能神经元在防御警报反应中具有一般功能，包括在热防御行为中起重要作用。
