Tercelj Marjeta, Salobir Barbara, Rylander Ragnar
Unit of Respiratory Diseases and Allergy, University Medical Center, Ljubljana, Slovenia.
Med Hypotheses. 2008;70(4):831-4. doi: 10.1016/j.mehy.2007.07.034. Epub 2007 Sep 11.
Increasing evidence suggests that the risk for sarcoidosis is related to exposure to microbes, particularly molds. Microbial cell wall agents, even in the absence of clinical infection, could cause a late hypersensitivity reaction leading to the formation of granulomas. A few interventions studies using antimicrobial treatment demonstrate improvement in sarcoidosis. It is suggested that diagnostic tools for the presence of microbes are used in patients with sarcoidosis and that antimicrobial treatment is considered in cases resistant to corticosteroids.
越来越多的证据表明，结节病的风险与接触微生物，尤其是霉菌有关。微生物细胞壁成分，即使在没有临床感染的情况下，也可能引发迟发性超敏反应，导致肉芽肿形成。一些使用抗菌治疗的干预性研究表明结节病病情有所改善。建议对结节病患者使用检测微生物存在的诊断工具，并在对皮质类固醇耐药的病例中考虑使用抗菌治疗。
