在微波辐射下通过α-亚氨基酯衍生物的分子内环化反应进行无溶剂内酰胺合成。
Solventless lactam synthesis by intramolecular cyclizations of alpha-iminoester derivatives under microwave irradiation.
作者信息
Zradni Fatima-Zohra, Hamelin Jack, Derdour Aicha
机构信息
Faculté des Sciences, Département de Chimie, Université d'Es-sénia, Oran, B.P 1524, Algeria.
出版信息
Molecules. 2007 Mar 12;12(3):439-54. doi: 10.3390/12030439.
Abstract
We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.
摘要
我们之前报道过在微波辐射下由酯类和胺类合成酰胺的新方法，该方法比传统加热方法的产率高得多[1]。现在，我们将这些研究扩展到在经典加热条件和微波辐射下，使纯亚胺酯I2、I3以及I4 - I6分别闭环生成五元环内酰胺L5、六元环内酰胺L6以及更大的内酰胺L7 - L9（其中I表示亚胺，L表示内酰胺）。
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