Malila Nea, Hakama Matti, Pukkala Eero
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Liisankatu 21 B, FI-001 70 Helsinki, Finland.
Acta Oncol. 2007;46(8):1103-6. doi: 10.1080/02841860701442531.
The aim of the study was to assess the feasibility of and possible selection to attend in colorectal cancer screening.
During the years 1979-1980, 1 785 men and women (born in 1917-1929) were invited to a pilot screening project for colorectal cancer. The screening method used was a guaiac-based faecal occult blood test repeated once if the initial test was positive.
Compliance was 69% and the test was positive in 19% of those attending. In a record linkage with the Finnish Cancer Registry, 47 colorectal cancer cases and 24 deaths from colorectal cancer were observed by the end of 2004. In all, the particular test method was not regarded specific enough for population screening. There was, however, no difference in cancer incidence between those who complied and those who did not when compared to the general population of same age and gender.
Compliance was found high enough to make screening feasible and there was no self selection of persons with low cancer risk to attend screening.
本研究的目的是评估参加结直肠癌筛查的可行性及可能的筛选情况。
在1979年至1980年期间，邀请了1785名男性和女性（出生于1917年至1929年）参加结直肠癌筛查试点项目。所采用的筛查方法是基于愈创木脂的粪便潜血试验，如果初次检测呈阳性则重复检测一次。
依从率为69%，参加检测者中有19%的检测结果呈阳性。在与芬兰癌症登记处的记录链接中，到2004年底观察到47例结直肠癌病例和24例因结直肠癌死亡的病例。总体而言，该特定检测方法对于人群筛查来说特异性不足。然而，与相同年龄和性别的普通人群相比，依从者和不依从者之间的癌症发病率没有差异。
发现依从率足够高，使得筛查可行，并且没有低癌症风险人群自行选择参加筛查的情况。
Zotero 插件