Zhengyu Song, Fang Wang, Ying Fan, Qinghua Qiu
Department of Ophthalmology, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, People's Republic of China.
Curr Eye Res. 2007 Jul-Aug;32(7-8):647-52. doi: 10.1080/02713680701447032.
To investigate the healing mechanism of the rabbit's sclerotomy sites undergoing the Transconjunctival Sutureless Vitrectomy (TSV).
Thirty-two rabbits (Thirty-two eyes) were divided into four groups: The rabbits performed with the core vitrectomy and air tamponade were Group A, performed with the core vitrectomy as Group B, performed with the non-core vitrectomy and air tamponade as Group C, and the non-core vitrectomy as Group D. The sclerotomy sites were observed by the Ultrasound Biomicroscope (UBM model 840, Humphrey Instruments, San Leandro, CA, USA) on days 1, 3, 5, and 9 postoperatively, and the diameter of the internal and the external aperture was estimated on postoperative day 1. The pathological study of the sclerotomy sites on days 3, 5, and 9 postoperatively were investigated under the light microscope.
The Ultrasound Biomicroscope and the pathological sections showed that the healing course of the sclerotomy sites lasted nine days. On postoperative day 1, the vitreous incarceration (19/32, 59.4%), the fluid cavity (18/32, 56.3%), and the air cavity under the conjunctiva (7/16, 43.8%) existed in some cases. The diameter of the internal aperture in Group A and Group B was less than Group C and Group D on day 1 postoperatively, P<0.001. The diameter of the external aperture did not show significant difference in any of the groups. The pathological study verified the healing course was the granulation reaction.
The healing mechanism of the rabbit's sclerotomy sites undergoing the (TSV) is the granulation reaction accompanied with the elastic recovery of the sclera.
研究兔眼经结膜无缝线玻璃体切除术（TSV）巩膜穿刺部位的愈合机制。
32只兔（32只眼）分为四组：行核心玻璃体切除联合空气填塞的兔为A组，行核心玻璃体切除的为B组，行非核心玻璃体切除联合空气填塞的为C组，行非核心玻璃体切除的为D组。术后第1、3、5和9天，用超声生物显微镜（型号840，美国加利福尼亚州圣莱安德罗市汉弗莱仪器公司）观察巩膜穿刺部位，并在术后第1天估计内口和外口直径。术后第3、5和9天对巩膜穿刺部位进行光镜下病理研究。
超声生物显微镜和病理切片显示，巩膜穿刺部位的愈合过程持续9天。术后第1天，部分病例存在玻璃体嵌顿（19/32，59.4%）、液腔（18/32，56.3%）和结膜下气腔（7/16，43.8%）。术后第1天，A组和B组的内口直径小于C组和D组，P<0.001。各实验组外口直径无明显差异。病理研究证实愈合过程为肉芽反应。
兔眼经TSV巩膜穿刺部位的愈合机制是肉芽反应伴巩膜弹性恢复。
