Rotman Research Institute, Baycrest, Ontario, Canada.
J Clin Exp Neuropsychol. 2008 Jan;30(1):18-32. doi: 10.1080/13803390601161166. Epub 2007 Apr 11.
Three commonly used clinical tests of frontal-executive function are verbal fluency, the Trail Making Test, and the Wisconsin Card Sorting Test, but few lesion studies of regional specificity within the frontal lobe (FL) exist for them. We examined 20 patients with right FL tumor resection, and mapped their damage to explore brain-behavior relations with greater precision. Across tests, the patients performed poorly and they also showed a deficit in switching but not clustering in verbal fluency. Within the right FL, however, we found none of the regional differences reported in studies of mixed-etiology FL patients, possibly due to the gradual neural reorganization that can occur with brain tumors. We discuss the importance of etiology in examining brain-behavior relations.
三种常用的额叶执行功能临床测试是词语流畅性测试、连线测试和威斯康星卡片分类测试，但针对它们的额叶（FL）内区域特异性的病变研究很少。我们检查了 20 名右侧 FL 肿瘤切除患者，并绘制了他们的损伤图，以更精确地探索脑-行为关系。在所有测试中，患者的表现都很差，他们在词语流畅性测试中也表现出转换但不是聚类的缺陷。然而，在右侧 FL 中，我们没有发现混合病因 FL 患者研究中报告的任何区域差异，这可能是由于脑肿瘤可能发生的逐渐神经重组。我们讨论了在检查脑-行为关系时病因的重要性。
