Gos Tomasz, Krell Dieter, Brisch Ralf, Bielau Hendrik, Trübner Kurt, Bernstein Hans-Gert, Bogerts Bernhard
Institute of Forensic Medicine, Medical University of Gdask, Gdask, Poland.
World J Biol Psychiatry. 2007;8(4):245-55. doi: 10.1080/15622970601169758.
The anterior cingulate cortex (AC) is consistently implicated in the pathophysiology of depression. While suicide has been shown in previous reports to be closely related to depression, it is still a distinct phenomenon. The aim to differentiate between depression and suicide was approached by the karyometric analysis of AC pyramidal neurons. The study was performed on paraffin-embedded brains from 20 depressive patients (10 of whom had committed suicide) and 24 matched controls. The karyometric parameters of the layer III and V pyramidal neurons of the dorsal and ventral AC were evaluated bilaterally by Argyrophilic Nucleolar Organiser (AgNOR) silver staining method. Control-specific was the increased nuclear area in ontogenetically younger pyramidal neurons layer III in the left dorsal compared with ventral AC (Wilcoxon test, P<0.01). The decreased AgNOR number per nucleus in these cells in the right ventral AC was depression-specific compared with controls (t-test, P=0.047). On the other hand, the diffuse decrease in AgNOR ratio throughout pyramidal neurons on the left side was specific for suicidal depressive patients compared with non-suicidal patients and controls (ANOVA, P=0.028). The results suggest that regionally differentiated depression- and suicide-specific disturbed function of the most important AC output cells exists in depressive patients.
前扣带回皮质（AC）一直被认为与抑郁症的病理生理学有关。虽然先前的报告显示自杀与抑郁症密切相关，但它仍然是一种独特的现象。通过对AC锥体神经元进行核仁测量分析来区分抑郁症和自杀。该研究对20名抑郁症患者（其中10人自杀）和24名匹配的对照者的石蜡包埋脑进行。采用嗜银核仁组织区（AgNOR）银染色法双侧评估背侧和腹侧AC的III层和V层锥体神经元的核仁测量参数。与腹侧AC相比，左侧背侧AC中发育较年轻的III层锥体神经元的核面积增加具有对照特异性（Wilcoxon检验，P<0.01）。与对照相比，右侧腹侧AC中这些细胞每个核的AgNOR数量减少具有抑郁症特异性（t检验，P=0.047）。另一方面，与非自杀患者和对照相比，左侧整个锥体神经元的AgNOR比率弥漫性降低对自杀性抑郁症患者具有特异性（方差分析，P=0.028）。结果表明，抑郁症患者中存在区域分化的、针对抑郁症和自杀的最重要AC输出细胞功能障碍。
