Schürhoff Franck, Laguerre Audrey, Roy Isabelle, Beaumont Jean-Louis, Leboyer Marion
AP-HP Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France.
World J Biol Psychiatry. 2008;9(2):121-5. doi: 10.1080/15622970701218679.
An excess of mixed-handedness has been repeatedly reported in schizophrenia and schizotypy. Handedness is a measure of atypical cerebral lateralization, which is considered as a risk factor for schizophrenia. Several studies have attempted to identify correlations between handedness and dimensions of psychosis but the results obtained so far remain inconclusive.
To explore a possible link between mixed-handedness and the three classical dimensions of psychosis. As speech and language disorders may be associated with cerebral lateralization, we predicted a correlation between mixed-handedness and disorganized dimension.
We used the Schizotypal Personality Questionnaire (SPQ) and the Edinburgh Handedness Inventory (EHI) to study the correlation between mixed-handedness scores and positive, negative or disorganized dimensions in a sample of 62 healthy subjects.
We found a negative correlation between mixed-handedness and the disorganized dimension of schizotypy, as individuals with prominent mixed-handedness showed more severe disorganization.
We have identified a link between mixed-handedness and the disorganized dimension that may help to identify genetic vulnerability factors involved in psychosis.
精神分裂症和分裂型人格障碍中反复出现混合利手过多的情况。利手是大脑非典型偏侧化的一种度量，被认为是精神分裂症的一个风险因素。多项研究试图确定利手与精神病维度之间的相关性，但迄今为止获得的结果仍无定论。
探讨混合利手与精神病的三个经典维度之间可能存在的联系。由于言语和语言障碍可能与大脑偏侧化有关，我们预测混合利手与紊乱维度之间存在相关性。
我们使用分裂型人格问卷（SPQ）和爱丁堡利手量表（EHI），在62名健康受试者样本中研究混合利手得分与阳性、阴性或紊乱维度之间的相关性。
我们发现混合利手与分裂型人格障碍的紊乱维度之间存在负相关，因为具有明显混合利手的个体表现出更严重的紊乱。
我们已经确定了混合利手与紊乱维度之间的联系，这可能有助于识别涉及精神病的遗传易感性因素。
