CART肽作为多巴胺和精神兴奋剂的调节剂以及与中脑边缘多巴胺能系统的相互作用。
CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system.
作者信息
Hubert George W, Jones Douglas C, Moffett Mark C, Rogge George, Kuhar Michael J
机构信息
Division of Neuroscience, The Yerkes National Primate Research Center of Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA.
出版信息
Biochem Pharmacol. 2008 Jan 1;75(1):57-62. doi: 10.1016/j.bcp.2007.07.028. Epub 2007 Jul 26.
Abstract
Cocaine- and amphetamine-regulated transcript (CART) peptides (CART 55-102 and CART 62-102) are peptidergic neurotransmitters that are widely but specifically distributed throughout the brain, gut and other parts of the body. They are found in many brain regions associated with drug addiction including the nucleus accumbens, ventral tegmental area and ventral pallidum. Injections of CART 55-102 into the nucleus accumbens have no effect on basal locomotor activity. However, an injection of CART just before an i.p. injection of cocaine reduces the locomotor activating effects of cocaine. These and other data suggest that CART in the accumbens blunts the effects of cocaine. A hypothesis is that CART is homeostatic in the accumbens and tends to oppose large increases in dopamine signaling. These actions would therefore be able to regulate the effects of some abused drugs such as the psychostimulants.
摘要
可卡因和苯丙胺调节转录肽（CART）（CART 55 - 102和CART 62 - 102）是肽能神经递质，广泛但特异性地分布于整个大脑、肠道和身体的其他部位。它们存在于许多与药物成瘾相关的脑区，包括伏隔核、腹侧被盖区和腹侧苍白球。向伏隔核注射CART 55 - 102对基础运动活动没有影响。然而，在腹腔注射可卡因之前注射CART可降低可卡因的运动激活作用。这些以及其他数据表明，伏隔核中的CART会减弱可卡因的作用。一种假设是，CART在伏隔核中具有稳态作用，倾向于对抗多巴胺信号的大幅增加。因此，这些作用能够调节一些滥用药物（如精神兴奋剂）的效果。
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