Wakami Kazuaki, Ohte Nobuyuki, Sakata Seiichiro, Kimura Genjiro
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
J Am Soc Echocardiogr. 2008 May;21(5):446-51. doi: 10.1016/j.echo.2007.08.002. Epub 2007 Sep 14.
Peak myocardial systolic strain determined using myocardial strain imaging is a useful index of left ventricular (LV) myocardial systolic function. We investigated the relationship between peak myocardial radial strain during early diastole and LV early diastolic function.
A total of 85 patients without localized LV wall-motion abnormality underwent myocardial strain imaging and diagnostic cardiac catheterization. Peak myocardial radial strain during early diastole was obtained at the LV posterior-sided wall in the short-axis image. Invasive parameters of LV function were determined during cardiac catheterization.
Peak myocardial radial strain during early diastole significantly correlated with both the time constant tau (r = 0.80, P < .0001) and the peak negative dP/dt (r = -0.64, P < .0001). Although it correlated with the LV ejection fraction, LV end-diastolic pressure, LV end-systolic volume index, and mean pulmonary capillary wedge pressure, the time constant tau was the prime determinant of peak myocardial radial strain during early diastole.
Peak myocardial radial strain during early diastole could be used to evaluate LV early diastolic function. Myocardial strain imaging is a promising noninvasive tool for assessing LV function in systole and early diastole.
使用心肌应变成像测定的心肌收缩期峰值应变是左心室（LV）心肌收缩功能的一个有用指标。我们研究了舒张早期心肌径向峰值应变与左心室舒张早期功能之间的关系。
共有85例无局限性左心室壁运动异常的患者接受了心肌应变成像和诊断性心导管检查。在短轴图像的左心室后壁获取舒张早期心肌径向峰值应变。在心导管检查期间测定左心室功能的有创参数。
舒张早期心肌径向峰值应变与时间常数tau（r = 0.80，P <.0001）和峰值负dP/dt（r = -0.64，P <.0001）均显著相关。尽管它与左心室射血分数、左心室舒张末期压力、左心室收缩末期容积指数和平均肺毛细血管楔压相关，但时间常数tau是舒张早期心肌径向峰值应变的主要决定因素。
舒张早期心肌径向峰值应变可用于评估左心室舒张早期功能。心肌应变成像是一种有前景的用于评估收缩期和舒张早期左心室功能的非侵入性工具。
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