Watanabe Yuichiro, Nunokawa Ayako, Kaneko Naoshi, Someya Toshiyuki
Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Niigata 951-8510, Japan.
Neurosci Res. 2007 Nov;59(3):322-6. doi: 10.1016/j.neures.2007.08.002. Epub 2007 Aug 15.
Serotonin (5-hydroxytryptamine [5-HT]) may be implicated in both the pathophysiology of schizophrenia and in mediating atypical antipsychotic drug effects. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme involved in the synthesis of 5-HT. Some genetic variants of the TPH1 gene have been tested for their associations with schizophrenia, but with conflicting results. To assess whether TPH1 is implicated in vulnerability to schizophrenia, we conducted a case-control association study (409 patients and 440 controls) for six single nucleotide polymorphisms in Japanese subjects and performed an updated meta-analysis. There were no significant associations between the polymorphisms or haplotypes of TPH1 and schizophrenia in our Japanese subjects. Our updated meta-analysis, which included six population-based case-control studies, suggests the possible involvement of the TPH1 218A allele in susceptibility to schizophrenia. To draw any conclusion, however, further studies using larger sample sizes should be carried out in various ethnic populations.
血清素（5-羟色胺[5-HT]）可能与精神分裂症的病理生理学以及介导非典型抗精神病药物的作用有关。色氨酸羟化酶（TPH）是参与5-HT合成的限速酶。已经对TPH1基因的一些遗传变异与精神分裂症的关联进行了测试，但结果相互矛盾。为了评估TPH1是否与精神分裂症易感性有关，我们在日本受试者中针对六个单核苷酸多态性进行了病例对照关联研究（409例患者和440例对照），并进行了更新的荟萃分析。在我们的日本受试者中，TPH1的多态性或单倍型与精神分裂症之间没有显著关联。我们更新的荟萃分析包括六项基于人群的病例对照研究，提示TPH1 218A等位基因可能与精神分裂症易感性有关。然而，要得出任何结论，都应该在不同种族人群中使用更大样本量进行进一步研究。
