关于《人类乳腺癌和结直肠癌的共有编码序列》的评论
Comment on "The consensus coding sequences of human breast and colorectal cancers".
作者信息
Rubin Alan F, Green Phil
机构信息
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
出版信息
Science. 2007 Sep 14;317(5844):1500. doi: 10.1126/science.1138956.
PMID:17872429
Abstract
Sjöblom et al. (Research Article, 13 October 2006, p. 268) reported many new genes with an apparent significant excess of mutations in breast and colorectal cancer. Reanalysis of their data with more appropriate statistical methods and background mutation rate assumptions reveals that few if any of these genes have significantly elevated mutation rates.
摘要
肖布洛姆等人（研究文章，2006年10月13日，第268页）报告了许多在乳腺癌和结直肠癌中明显存在大量突变的新基因。用更合适的统计方法和背景突变率假设对他们的数据重新分析后发现，这些基因中几乎没有（如果有的话）突变率显著升高的情况。
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