Quagliato Lucas Barasnevicius, Viana Maura Aparecida, Quagliato Elizabeth Maria Aparecida Barasnevicius, Simis Samuel
Departamento de Neurologia, Faculdade de Ciências Médicas, Pontifícia Universidade Católica de São Paulo, Sorocaba, SP, Brasil.
Arq Neuropsiquiatr. 2007 Sep;65(3A):647-52. doi: 10.1590/s0004-282x2007000400020.
To characterize the olfactory dysfunction in 50 Parkinson's disease (PD) patients with the University of Pennsylvania 12 smell identification test (UPSIT), establishing a comparison with 76 age-matched healthy controls, and associate with clinical and epidemiologic picture.
The PD group was evaluated in phase "on" through United Parkinson's disease rating scale, UPSIT, and Hoehn and Yahr stage and the control group with the UPSIT.
The mean UPSIT score was 5.7 in PD patients and 9 in the control group. Patients that presented initially resting tremor and those that currently have tremor, rigidity and bradykinesia had a significant lower scores. There were negative correlation between patients' age and PD stage with the UPSIT scores. There were no correlation between olfactory scores, age at the initial PD symptoms and disease duration.
Among PD patients 80% had olfactory deficit and, therefore, smell evaluation may be a tool to make PD differential diagnosis.
采用宾夕法尼亚大学12项嗅觉识别测试（UPSIT）对50例帕金森病（PD）患者的嗅觉功能障碍进行特征描述，与76例年龄匹配的健康对照者进行比较，并将其与临床和流行病学情况相关联。
通过统一帕金森病评定量表、UPSIT以及霍恩和亚尔分期对PD组患者“开”期进行评估，对照组仅采用UPSIT进行评估。
PD患者的UPSIT平均得分为5.7分，对照组为9分。最初出现静止性震颤的患者以及目前有震颤、强直和运动迟缓的患者得分显著较低。患者年龄和PD分期与UPSIT得分呈负相关。嗅觉评分、初始PD症状出现时的年龄与病程之间无相关性。
80%的PD患者存在嗅觉缺陷，因此，嗅觉评估可能是进行PD鉴别诊断的一种工具。
