Ikenouchi-Sugita Atsuko, Yoshimura Reiji, Nakamura Jun
Department of Psychiatry, University of Occupational and Environmental Health.
Nihon Rinsho. 2007 Sep;65(9):1633-7.
We reviewed the pharmacological efficacies and side effects of antidepressants. Selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenaline reuptake inhibitors (SNRIs) are most popularly prescribed for anxiety disorders as well as mild or moderate depression. These drugs have less orthostatic, cognitive, cardiovascular, and anticholinergic side effects. Tricyclic antidepressants are still important for treating severe depression, and mianserin and trazodone are useful for treating delirium. Clinicians should select antidepressants considering their pharmacologic profiles and avoiding adverse effects.
我们回顾了抗抑郁药的药理疗效和副作用。选择性5-羟色胺再摄取抑制剂（SSRI）和5-羟色胺去甲肾上腺素再摄取抑制剂（SNRI）是治疗焦虑症以及轻、中度抑郁症最常用的药物。这些药物的体位性、认知性、心血管性和抗胆碱能副作用较少。三环类抗抑郁药在治疗重度抑郁症方面仍然很重要，米安色林和曲唑酮对治疗谵妄有效。临床医生应根据抗抑郁药的药理特性选择药物，并避免不良反应。
