Rosline H, Roshan T M, Ahmed S A, Ilunihayati I
Department of Hematology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kelantan.
Southeast Asian J Trop Med Public Health. 2007 May;38(3):543-5.
Thalassemia is a common public health problem among Malays. Hemoglobin C (Hb C) is a hemoglobin beta variant resulting from a single base mutation at the 6th position of the beta-globin gene leading to the substitution of glycine for glutamic acid. Hb C is commonly detected in West Africans and in African American but has not been reported in Malaysia. It can be falsely diagnosed as HbE trait in the Malaysian Thalassemia Screening Program which utilizes cellulose acetate hemoglobin electrophoresis. This is the first reported case of Hb AC heterozygote status in a Malay family, with unusual splenomegaly in one of the family members.
地中海贫血是马来西亚人中常见的公共卫生问题。血红蛋白C（Hb C）是一种血红蛋白β变体，由β-珠蛋白基因第6位的单个碱基突变导致甘氨酸取代谷氨酸。Hb C在西非人和非裔美国人中常见，但在马来西亚尚未有报道。在马来西亚地中海贫血筛查项目中，利用醋酸纤维素血红蛋白电泳时，它可能被误诊为HbE特征。这是首次报道的一个马来家庭中Hb AC杂合子状态的病例，其中一名家庭成员有不寻常的脾肿大。
