Kulshreshtha S, Sharma P, Mohan G, Singh Sunita, Singh Saroj
Department of Pharmacology, S.N. Medical College and Associated Hospitals, Agra.
Indian J Physiol Pharmacol. 2007 Jan-Mar;51(1):55-61.
Various methods of induction of labour may be associated with risk and complications. Therefore, this study has been undertaken to compare the safety and efficacy of intra-vaginal misoprostol (PGE1 analogue) with intra-cervical dinoprostone (PGE2) in progress and induction of labour, the maternal side effects and the foetal outcome. 40 pregnant women aged between 16-35 years with indication of induction of labour participated in the study. Twenty patients (control) were administered 0.5 mg dinoprostone intra-cervically, 12 hourly while 20 patients (study group) were given misoprostol 100 microg, 4 hourly, intravaginally. The mean induction of labour initiation interval was 2.08 +/- 1.46 hours in study group and 2.21 +/- 1.20 hours in dinoprostone group. The Induction delivery interval was 6.92 +/- 4.01 hours in misoprostol group and 12.54 +/- 7.73 in dinoprostone group, whereas vaginal route of delivery was 95% in misoprostol group and 85% in dinoprostone group. Average dosages required were 1.55 +/- 1.02 in misoprostol group and 1.30 +/- 0.46 in dinoprostone group. All these result were statistically significant. Very few maternal side effects were reported in study group. There was no significant difference in foetal out come in either group. Therefore, it can be concluded that misoprostol is easy to administer and is cheap, effective, safe and convenient drug for induction of labour.
各种引产方法可能都伴有风险和并发症。因此，本研究旨在比较阴道内使用米索前列醇（PGE1类似物）与宫颈内使用地诺前列酮（PGE2）在引产及促宫颈成熟方面的安全性和有效性、产妇副作用及胎儿结局。40名年龄在16至35岁之间有引产指征的孕妇参与了本研究。20名患者（对照组）宫颈内给予0.5mg地诺前列酮，每12小时一次，而20名患者（研究组）阴道内给予100μg米索前列醇，每4小时一次。研究组引产开始间隔的平均时间为2.08±1.46小时，地诺前列酮组为2.21±1.20小时。米索前列醇组引产至分娩间隔为6.92±4.01小时，地诺前列酮组为12.54±7.73小时，米索前列醇组经阴道分娩率为95%，地诺前列酮组为85%。米索前列醇组所需平均剂量为1.55±1.02，地诺前列酮组为1.30±0.46。所有这些结果均具有统计学意义。研究组报告的产妇副作用很少。两组胎儿结局均无显著差异。因此，可以得出结论，米索前列醇易于给药，是一种用于引产的廉价、有效、安全且方便的药物。
