Lim Michael, Bower Regina, Nangiana Jasvinder Singh, Adler John R, Chang Steven D
Department of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA.
Technol Cancer Res Treat. 2007 Oct;6(5):419-23. doi: 10.1177/153303460700600507.
Results for treating glomus jugulare tumors with radiosurgery have been limited by short follow-up and small number of patients. We report our experience using LINAC or CyberKnife in 21 tumors with a median follow-up of 66 months (Mean follow-up of 60 months). In addition, we have a subset of eight patients that were followed out for more than 10 years. Patients were treated with doses ranging from 1400 cGy to 2700 cGy. We retrospectively assessed patients for efficacy and post treatment side effects. All patients had stable neurological symptoms, and two patients experienced transient ipsilateral tongue weakness and hearing loss, both of which subsequently resolved. One patient experienced transient ipsilateral vocal cord paresis; however, this patient received previous external beam radiotherapy. All tumors remained stable or decreased in size by MRI exam. Our results support radiosurgery as an effective and safe method of treatment for glomus jugulare tumors with low morbidity as evidenced by a larger number of patients and long term follow-up.
放射外科治疗颈静脉球瘤的结果因随访时间短和患者数量少而受到限制。我们报告了使用直线加速器(LINAC)或射波刀(CyberKnife)治疗21例肿瘤的经验,中位随访时间为66个月(平均随访时间为60个月)。此外,我们有一组8例患者的随访时间超过了10年。患者接受的剂量范围为1400 cGy至2700 cGy。我们对患者的疗效和治疗后副作用进行了回顾性评估。所有患者的神经症状均稳定,2例患者出现短暂的同侧舌肌无力和听力丧失,但随后均恢复。1例患者出现短暂的同侧声带麻痹;然而,该患者之前接受过外照射放疗。通过MRI检查,所有肿瘤均保持稳定或体积缩小。我们的结果支持放射外科作为治疗颈静脉球瘤的一种有效且安全的方法,其发病率较低,这一点已通过更多患者数量和长期随访得到证明。