Collin M P, Bogunovic M, Merad M
Department of Gene and Cell Medicine, Mount Sinai Medical School, New York, New York 10029, USA.
Cytotherapy. 2007;9(6):521-31. doi: 10.1080/14653240701507314.
Hematopoietic stem cell transplantation is an important experimental tool and therapeutic modality. Its efficacy and toxicity are both linked to a GvH reaction that is initiated by donor T cells recognizing recipient APC, of which DC are the most potent. In most tissues recipient DC are replaced after transplantation because they turnover rapidly from BM-derived precursors. However, in a number of sites, notably the skin, recipient DC may persist and even self-renew for many months after transplantation. Understanding the homeostasis of different APC populations and how they are related to the induction of alloreactivity may help to improve the therapeutic benefit of transplantation.
造血干细胞移植是一种重要的实验工具和治疗方式。其疗效和毒性均与移植物抗宿主（GvH）反应相关，该反应由供体T细胞识别受体抗原呈递细胞（APC）引发，其中树突状细胞（DC）最为有效。在大多数组织中，移植后受体DC会被替换，因为它们会迅速从骨髓来源的前体细胞更新换代。然而，在一些部位，尤其是皮肤，受体DC可能会在移植后持续存在甚至自我更新数月。了解不同APC群体的稳态及其与同种异体反应诱导的关系，可能有助于提高移植的治疗效果。
Cytotherapy. 2007
Trends Immunol. 2007-8
Blood Cells Mol Dis. 2008
Rev Prat. 2008-12-15
Exp Dermatol. 2014-4
Expert Rev Hematol. 2010-8
Zotero 插件