Silva P, Homer J J, Slevin N J, Musgrove B T, Sloan P, Price P, West C M L
Academic Department of Radiation Oncology, The University of Manchester, Manchester, UK.
Clin Otolaryngol. 2007 Oct;32(5):337-45. doi: 10.1111/j.1749-4486.2007.01544.x.
The main aim of this article was to review the clinical and biological factors that have been shown to influence the response of the head and neck squamous cell carcinoma (HNSCC) to primary radiotherapy and briefly discuss how some of these factors could be exploited to improve outcome.
Medline based search covering 1982-2006 to identify the HNSCC literature where the effect of clinical and biological factors on locoregional control and overall survival were investigated.
Clinical factors are routinely used in management decisions. Nevertheless, identically staged tumours receiving the same treatment may have different outcomes. Biological factors such as hypoxia, proliferation and radio-sensitivity play an important role in radiation response. However, these are not currently used in practise because tests that are clinically reliable and feasible are not available.
High-quality translational research will allow us to develop biological tests that can be used in routine clinical practise to tailor individual treatment, with the ability to improve patient outcome further by modifying the underlying tumour biology.
本文的主要目的是回顾已被证明影响头颈部鳞状细胞癌（HNSCC）对原发性放射治疗反应的临床和生物学因素，并简要讨论如何利用其中一些因素来改善治疗结果。
基于Medline的搜索，涵盖1982年至2006年，以识别研究临床和生物学因素对局部区域控制和总生存影响的HNSCC文献。
临床因素在管理决策中经常使用。然而，接受相同治疗的分期相同的肿瘤可能有不同的结果。缺氧、增殖和放射敏感性等生物学因素在放射反应中起重要作用。然而，由于目前尚无临床可靠且可行的检测方法，这些因素目前未在实践中应用。
高质量的转化研究将使我们能够开发可用于常规临床实践的生物学检测方法，以定制个体化治疗，并通过改变潜在的肿瘤生物学特性进一步改善患者的治疗结果。
