西班牙210例成人和儿童肥大细胞增多症患者的过敏和过敏症状患病率：西班牙肥大细胞增多症网络（REMA）研究

Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA).

作者信息

González de Olano D, de la Hoz Caballer B, Núñez López R, Sánchez Muñoz L, Cuevas Agustín M, Diéguez M C, Alvarez Twose I, Castells M C, Escribano Mora L

机构信息

Allergy Department, Hospital Ramón y Cajal, Madrid, Spain.

出版信息

Clin Exp Allergy. 2007 Oct;37(10):1547-55. doi: 10.1111/j.1365-2222.2007.02804.x.

DOI:10.1111/j.1365-2222.2007.02804.x

PMID:17883734

Abstract

BACKGROUND

Mast cells (MCs) play a key role in allergic diseases through the release of inflammatory mediators, which are responsible of allergic symptoms. Mastocytosis is characterized by an abnormal proliferation and accumulation of mast cells, in which mediators are released intermittingly or continuously. Despite these clinical similarities, few studies have addressed the presence of allergic symptoms in mastocytosis patients, including anaphylaxis.

OBJECTIVE

A prospective evaluation was carried out to study the prevalence of allergic diseases in patients with mastocytosis and their impact on the natural history of mastocytosis.

METHODS

A questionnaire was given to 210 patients with mastocytosis to evaluate the history of asthma, rhinitis, conjunctivitis, atopic dermatitis, urticaria and anaphylaxis. Patients underwent total IgE, Phadiatop infant (aeroallergens and food allergens), specific IgE to latex and to Anisakis simplex determinations. Skin tests were done to 72 patients.

RESULTS

The prevalence of allergy, as defined by clinical symptoms associated to specific IgE, was 23.9%. Total IgE level was significantly higher in patients with allergy as compared with patients without allergy (median 58 vs. 16.5 kU/L, P<0.0001). Anaphylactic symptoms were present in 36 patients (22%), in nine the allergen was identified. Males had more allergy and anaphylactic symptoms than females (61.5% vs. 38.5% and 72% vs. 28%, respectively).

CONCLUSIONS

Allergic diseases coexist in patients with mastocytosis with similar frequency as compared with the general population. Anaphylactic symptoms are more prevalent in males with mastocytosis and in patients with elevated IgE.

CAPSULE SUMMARY

The prevalence of allergy in mastocytosis is similar to the general population. Anaphylactic symptoms are more prevalent in males and in patients with elevated IgE. The coexistence of atopy does not influence mastocytosis-associated symptoms.

摘要

背景

肥大细胞（MCs）通过释放炎症介质在过敏性疾病中起关键作用，这些炎症介质会引发过敏症状。肥大细胞增多症的特征是肥大细胞异常增殖和积聚，其中介质会间歇性或持续性释放。尽管存在这些临床相似性，但很少有研究探讨肥大细胞增多症患者中过敏症状的存在情况，包括过敏反应。

目的

进行一项前瞻性评估，以研究肥大细胞增多症患者中过敏性疾病的患病率及其对肥大细胞增多症自然病程的影响。

方法

对210例肥大细胞增多症患者进行问卷调查，以评估哮喘、鼻炎、结膜炎、特应性皮炎、荨麻疹和过敏反应的病史。患者接受总IgE、Phadiatop婴儿检测（吸入性变应原和食物变应原）、针对乳胶和简单异尖线虫的特异性IgE检测。对72例患者进行了皮肤试验。

结果

根据与特异性IgE相关的临床症状定义的过敏患病率为23.9%。与无过敏患者相比，过敏患者的总IgE水平显著更高（中位数分别为58和16.5 kU/L，P<0.0001）。36例患者（22%）出现过敏反应症状，其中9例确定了变应原。男性的过敏和过敏反应症状比女性更多（分别为61.5%对38.5%和72%对28%）。