Xu Lin-Yong, He Yi-Jing, Zhang Wei, Deng Sheng, Li Qing, Zhang Wei-Xia, Liu Zhao-Qian, Wang Dan, Huang Yuan-Fei, Zhou Hong-Hao, Sun Zhen-Qiu
Department of Epidemic and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
Acta Pharmacol Sin. 2007 Oct;28(10):1693-7. doi: 10.1111/j.1745-7254.2007.00643.x.
To detect 388G>A and 521T>C variant alleles in the organic anion transporting polypeptide-1B1 (OATP1B1, encoding gene SLCO1B1) gene.
One hundred and eleven healthy volunteers were screened for OATP1B1 alleles in our study. PCR-restriction fragment length polymorphism was used to identify the 388G>A polymorphism and a 1-step tetra-primer method was developed for the determination of 521T>C mutation.
The frequencies of the 388G>A and 521T>C variant alleles in the Chinese population were 73.4% and 14.0%, respectively. The frequencies of the SLCO1B1*1b and *15 haplotypes were 59.9% and 14.0%, respectively.
The SLCO1B11b and SLCO1B115 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.
检测有机阴离子转运多肽1B1（OATP1B1，编码基因SLCO1B1）基因中的388G>A和521T>C变异等位基因。
本研究对111名健康志愿者进行了OATP1B1等位基因筛查。采用聚合酶链反应-限制性片段长度多态性方法鉴定388G>A多态性，并建立一步四引物法测定521T>C突变。
中国人群中388G>A和521T>C变异等位基因的频率分别为73.4%和14.0%。SLCO1B11b和15单倍型的频率分别为59.9%和14.0%。
SLCO1B11b和SLCO1B115变异在中国人群中相对常见。它们的频率与日本人相似，但与白种人和黑人有显著差异。
Zotero 插件