Frey Benicio N, Walss-Bass Consuelo, Stanley Jeffrey A, Nery Fabiano G, Matsuo Koji, Nicoletti Mark A, Hatch John P, Bowden Charles L, Escamilla Michael A, Soares Jair C
Department of Psychiatry, Psychiatric Genetics Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Neuroreport. 2007 Oct 8;18(15):1567-70. doi: 10.1097/WNR.0b013e3282ef7082.
Brain-derived neurotrophic factor val66met polymorphism has been implicated in the pathophysiology of bipolar disorder. We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy. Absolute N-acetyl-aspartate, phosphocreatine+creatine (PCr+Cr), choline-containing compounds, myo-inositol, and glutamate levels were measured. Bipolar disorder met-carriers had lower PCr+Cr levels than bipolar disorder val/val patients, and bipolar disorder val/val patients had higher PCr+Cr levels than val/val healthy controls. These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex.
脑源性神经营养因子Val66Met多态性与双相情感障碍的病理生理学有关。我们使用氢磁共振波谱研究了双相情感障碍患者和健康参与者左背外侧前额叶皮质的神经化学与脑源性神经营养因子Val66Met多态性的关系。测量了N-乙酰天门冬氨酸、磷酸肌酸+肌酸（PCr+Cr）、含胆碱化合物、肌醇和谷氨酸的绝对水平。双相情感障碍Met携带者的PCr+Cr水平低于双相情感障碍Val/Val患者，而双相情感障碍Val/Val患者的PCr+Cr水平高于Val/Val健康对照。这些结果表明，双相情感障碍Met携带者左背外侧前额叶皮质存在能量代谢异常。
