Bergren Dale R
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, U.S.A.
J Asthma. 2007 Sep;44(7):529-34. doi: 10.1080/02770900701496080.
Tobacco smoke (TS) exposure can induce airway hyperresponsiveness, especially in asthma. A feature of asthma is eosinophilia. We hypothesized that tobacco smoke exposure enhances eosinophil responsiveness in sensitized guinea pigs. Tobacco smoke-exposed, ovalbumin (OA)-sensitized guinea pigs were treated with TRFK-5 (1.0 mg/kg, intraperitoneal), an anti-interleukin (IL)-5 agent, or its vehicle. Guinea pigs were challenged with aerosols of OA, capsaicin, histamine, and methacholine. TRFK-5 attenuated airway responsiveness to OA but not to capsaicin, histamine, or methacholine. Bronchial alveolar lavage fluid analysis confirmed TRFK-5 attenuated airway eosinophilia in OA-treated guinea pigs. Therefore, airway responsiveness to OA is enhanced by eosinophils or IL-5 itself.
接触烟草烟雾（TS）可诱发气道高反应性，在哮喘患者中尤为如此。哮喘的一个特征是嗜酸性粒细胞增多。我们假设，接触烟草烟雾会增强致敏豚鼠的嗜酸性粒细胞反应性。将接触烟草烟雾、对卵清蛋白（OA）致敏的豚鼠用抗白细胞介素（IL）-5药物TRFK-5（1.0毫克/千克，腹腔注射）或其赋形剂进行处理。用OA、辣椒素、组胺和乙酰甲胆碱气雾剂对豚鼠进行激发试验。TRFK-5减弱了气道对OA的反应性，但对辣椒素、组胺或乙酰甲胆碱的反应性无影响。支气管肺泡灌洗 fluid分析证实，TRFK-5减弱了OA处理的豚鼠气道中的嗜酸性粒细胞增多现象。因此，嗜酸性粒细胞或IL-5本身会增强气道对OA的反应性。 （注：原文中“Bronchial alveolar lavage fluid analysis”的“fluid”可能有误，推测应为“fluid”，翻译为“支气管肺泡灌洗液体分析”，这里按推测翻译了，若原文准确单词不是“fluid”，请根据实际情况调整。）
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