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切花种植农户中的急性农药中毒情况。

Acute pesticide poisoning among cut-flower farmers.

作者信息

Lu Jinky Leilanie

机构信息

University of the Philippines, National Institutes of Health, Quezon City.

出版信息

J Environ Health. 2007 Sep;70(2):38-43.

Abstract

The study reported here looked at adverse health effects associated with pesticide exposure among cut-flower farmers in La Trinidad, Philippines. Survey questionnaires and detailed physical and laboratory examinations were administered to 114 and 102 respondents, respectively, to determine pesticide exposure, work and safety practices, individual and family illnesses, and cholinesterase levels. Results showed that pesticide application was the activity most frequently associated with pesticide exposure, and entry was mostly ocular and dermal. Involvement of the skin was noted, with 21 percent of farmers having integumentary abnormalities. Upon physical examination, 90 respondents, or 88.2 percent of those examined, were found to have abnormal peak expiratory flow rate (PEFR). Abnormal temperature was found in 81.3 percent, and the next most frequent finding was abnormal general-survey results, at 75.5 percent. In 51 percent, cholinesterase levels were below the mean value of 0.7 delta pH/hour. (The unit of measure A pH/hour refers to the change in cholinesterase activity as measured by the difference between the initial pH and the final pH when acetylcholine solution has been added to the red blood cell for 1 1/2 hours. A decrease in cholinesterase activity will produce a low delta pH/hour level) In 25.5 percent, a more than 10 percent depression in the level of RBC cholinesterase was found. Certain hematological parameters were also abnormal, namely hemoglobin, hematocrit, and eosinophil count. Using Pearson's r, the author found that factors strongly associated with illness due to pesticides include use of a contaminated piece of fabric to wipe off sweat (p = .01) and reuse of pesticide containers to store water (p = .01), Recycling of containers poses great health hazards and risks of contamination, and the current recommendation is that used containers should be buried. There was a moderate relationship between illness and average number of years of pesticide use (p = .05), and between illness and re-entering a recently sprayed area (p = .05). Those with motor scale scores of < or = 15--normal values--were less likely to be sick. The greatest adverse effect in those exposed was an abnormal cholinesterase level, a finding that confirms results from earlier studies on the effect of pesticides on the body.

摘要

本文所报告的研究着眼于菲律宾拉特里尼达切花种植农民中与接触农药相关的健康不良影响。分别对114名和102名受访者进行了调查问卷以及详细的身体和实验室检查,以确定农药接触情况、工作和安全习惯、个人及家庭疾病以及胆碱酯酶水平。结果显示,施用农药是与农药接触最常相关的活动,接触途径主要是眼睛和皮肤。注意到皮肤有受累情况,21%的农民有皮肤异常。经身体检查,90名受访者(即接受检查者中的88.2%)被发现呼气峰值流速(PEFR)异常。81.3%的人有体温异常,其次最常见的检查结果异常是一般检查结果异常,占75.5%。51%的人胆碱酯酶水平低于0.7ΔpH/小时的平均值。(测量单位ΔpH/小时指的是当向红细胞中加入乙酰胆碱溶液1.5小时后,通过初始pH值与最终pH值之差测量的胆碱酯酶活性变化。胆碱酯酶活性降低会导致ΔpH/小时水平较低)25.5%的人红细胞胆碱酯酶水平下降超过10%。某些血液学参数也异常,即血红蛋白、血细胞比容和嗜酸性粒细胞计数。作者使用皮尔逊相关系数r发现,与农药导致的疾病密切相关的因素包括使用受污染的织物擦汗(p = 0.01)以及重复使用农药容器储存水(p = 0.01),容器的回收利用带来极大的健康危害和污染风险,目前的建议是将用过的容器掩埋。疾病与农药使用平均年数之间存在中等程度的关联(p = 0.05),疾病与重新进入近期喷洒过农药的区域之间也存在中等程度的关联(p = 0.05)。运动量表评分≤15(正常值)的人患病可能性较小。接触农药者中最严重的不良影响是胆碱酯酶水平异常,这一发现证实了早期关于农药对身体影响的研究结果。

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