Nakato Tomofumi, Yamauchi Satoshi
Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan.
J Nat Prod. 2007 Oct;70(10):1588-92. doi: 10.1021/np070300v. Epub 2007 Sep 22.
The optically pure trisubstituted 7'-oxotetrahydrofuran lignans (-)- and (+)-magnolone ( 1) were synthesized by employing stereoselective S N1 intramolecular cyclization as a key reaction. The absolute configuration of naturally occurring (-)-magnolone was determined as (7 S,8 R,8' S).
通过将立体选择性SN1分子内环化作为关键反应,合成了光学纯的三取代7'-氧代四氢呋喃木脂素(-)-和(+)-厚朴脂素(1)。天然存在的(-)-厚朴脂素的绝对构型确定为(7S,8R,8'S)。