Jaillais Yvon, Santambrogio Martina, Rozier Frédérique, Fobis-Loisy Isabelle, Miège Christine, Gaude Thierry
Reproduction et Développement des Plantes, Institut Fédératif de Recherche 128, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université Claude Bernard Lyon I, Ecole Normale Supérieure de Lyon, Lyon, France.
Cell. 2007 Sep 21;130(6):1057-70. doi: 10.1016/j.cell.2007.08.040.
A key feature of plants (as opposed to animals) is their ability to establish new organs not only during embryogenesis, but also throughout their development. A master regulator of organ initiation in plants is the phytohormone auxin. Auxin acts locally as a morphogen and is directionally transported from cell to cell by polarized auxin efflux carriers, termed PIN-FORMED (PIN) proteins. Here we report that the Arabidopsis ortholog of the yeast and mammalian vacuolar protein sorting 29 (VPS29), a member of the retromer complex, mediates the formation of new axes of development. Furthermore, we show that VPS29 is required for endosome homeostasis, PIN protein cycling, and dynamic PIN1 repolarization during development. We propose a model that links VPS29 function, PIN1 polarity, and organ initiation in plants.
植物（与动物相对）的一个关键特征是它们不仅在胚胎发生过程中，而且在整个发育过程中都具有形成新器官的能力。植物器官起始的主要调节因子是植物激素生长素。生长素作为一种形态发生素在局部起作用，并通过极化的生长素流出载体（称为PIN形成蛋白，即PIN蛋白）在细胞间定向运输。在这里，我们报告酵母和哺乳动物液泡蛋白分选29（VPS29）的拟南芥直系同源物（逆转复合体的成员）介导了新发育轴的形成。此外，我们表明VPS29是发育过程中内体稳态、PIN蛋白循环和动态PIN1重新极化所必需的。我们提出了一个将VPS29功能、PIN1极性和植物器官起始联系起来的模型。
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