免疫调节雄甾烷和豆甾烷的合成：它们对肿瘤坏死因子-α抑制活性的比较。
Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity.
作者信息
Ramírez Javier A, Bruttomesso Andrea C, Michelini Flavia M, Acebedo Sofía L, Alché Laura E, Galagovsky Lydia R
机构信息
Departamento de Química Orgánica and UMYMFOR (CONICET-Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA, Buenos Aires, Argentina.
出版信息
Bioorg Med Chem. 2007 Dec 15;15(24):7538-44. doi: 10.1016/j.bmc.2007.09.012. Epub 2007 Sep 14.
In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-alpha production by macrophages. A preliminary qualitative structure-activity relationship was established.
在之前的一项工作中，我们的团队表明一些合成豆甾烷可能在免疫介导的炎症中发挥作用。在本文中，我们报道了一系列从脱氢表雄酮和豆甾醇衍生而来的新型甾体化合物的合成，以及它们对巨噬细胞产生肿瘤坏死因子-α的体外抑制活性的评估。建立了初步的定性构效关系。
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