Guillemot François
National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK.
Development. 2007 Nov;134(21):3771-80. doi: 10.1242/dev.006379. Epub 2007 Sep 26.
The vertebrate central nervous system contains a great diversity of neurons and glial cells, which are generated in the embryonic neural tube at specific times and positions. Several classes of transcription factors have been shown to control various steps in the differentiation of progenitor cells in the neural tube and to determine the identity of the cells produced. Recent evidence indicates that combinations of transcription factors of the homeodomain and basic helix-loop-helix families establish molecular codes that determine both where and when the different kinds of neurons and glial cells are generated.
脊椎动物的中枢神经系统包含种类繁多的神经元和神经胶质细胞，它们在胚胎神经管的特定时间和位置产生。已表明几类转录因子可控制神经管中祖细胞分化的各个步骤，并确定所产生细胞的特性。最近的证据表明，同源结构域和碱性螺旋-环-螺旋家族的转录因子组合建立了分子编码，这些编码决定了不同种类的神经元和神经胶质细胞在何处以及何时产生。
