Vázquez Mezquita M, García Satue J L, Fernández Francés J, Prados Sánchez C, García del Río F, Muñoz Méndez J, de Ramón Casado A, Rodríguez Bolado P
Servicio de Neumología, Ciudad Sanitaria La Paz.
An Med Interna. 1991 Nov;8(11):566-8.
Tuberculosis is still a major international public health problem. The role of vaccination with BCG in the prophylaxis of the tuberculosis has been a source of controversy almost since ist introduction in the thirties, because of the disparity of the results regarding efficacy and protection of the several studies that have been done. Currently, everybody seems to agree that in countries with annual infection risk lower than 1%, a massive vaccination campaign with BGC is not profitable. On the other hand, BCG interferes the lecture of the Mantoux intra-dermo-reaction and, thus, it invalidates the most effective test that we have for the diagnosis of the tuberculosis infection. In our country, the battle against tuberculosis is currently focused on the identification and treatment of the tuberculous patient, chemoprophylaxis with contacts of these patients and avoidance of the development of the tuberculosis infection to tuberculosis disease.
结核病仍然是一个重大的国际公共卫生问题。卡介苗接种在预防结核病中的作用自30年代引入以来几乎一直存在争议,因为已开展的多项研究在疗效和保护作用方面结果存在差异。目前,似乎大家都认同,在年感染风险低于1%的国家,大规模接种卡介苗并无益处。另一方面,卡介苗会干扰结核菌素皮内反应的解读,因此,它会使我们用于诊断结核感染的最有效检测方法失效。在我国,当前抗击结核病的重点在于识别和治疗结核病患者、对这些患者的接触者进行化学预防以及避免结核感染发展为结核病。